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Symbol
Name
ID

Psen2
presenilin 2
MGI:109284

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Neurofibrillary tangles	Alzheimer disease	Senile plaques	Apraxia	Cognitive impairment	Memory impairment	Dementia	Sleep-wake cycle disturbance	Parietal hypometabolism in FDG PET
Disease(s) Associated with PSEN2	Neurofibrillary tangles	Alzheimer disease	Senile plaques	Apraxia	Cognitive impairment	Memory impairment	Dementia	Sleep-wake cycle disturbance	Parietal hypometabolism in FDG PET
Alzheimer's disease 4
dilated cardiomyopathy 1V

Mouse Phenotypes		nervous system phenotype	abnormal brain morphology	hydrocephaly
Availability	Mouse Genotype	nervous system phenotype	abnormal brain morphology	hydrocephaly
	Psen2^{em1(IMPC)Ccpcz}/Psen2^{em1(IMPC)Ccpcz}
	Psen2^tm1Bdes/Psen2^tm1Bdes	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23